Diagnosis of Leptomeningeal Metastases Disease
in MRI Images by Using Image Enhancement
Methods
Mehmet Gül1,
Sadık Kara1, Abdurrahman Işıkdoğan2, and Yusuf Yarar3
1Biomedical Engineering Institute, Fatih University,
Istanbul
2Hospital of Oncology, Dicle University, Diyarbakır
3Selahaddin’i Eyyubi Hospital, Diyarbakır
Abstract: Leptomeningeal Metastases (LM) disease is the advanced stages of
some complicated cancers. It Contaminates in the Cerebrospinal Fluid (CSF).
Tumors might be in macroscopic or microscopic sizes. The medical operation is
more risky than other cancers. Consequently, diagnosis of leptomeningeal
metastases is important. Different methods are used to diagnose LM disease such
as CSF examination and imaging systems Magnetic Resonance Imaging (MRI) or Computer
Tomography (CT) examination. CSF examination result is more accurate compared
to CT or MRI imaging systems. However imaging systems’ results are taken more
early than CSF examination. Some details in MRI images are hidden and if the
proper image enhancement method is used, the details will be revealed.
Diagnosis of LM disease can be earlier with accurate results at that time. In
this study, some image enhancement methods were used. The probability of result
of Logarithmic Transformation (LT) method and Power-Law Transformation (PLT)
method were almost the same and result was p=0.000 (p<0.001), and
statistically high result was obtained. The probability of Contrast Stretching (CS)
method was p=0.031 (p<0.05), and this result was statistically significant.
The other four methods’ results were insignificant. These methods are Image
Negatives Transformation (INT) method, thresholding transformations method; Gray-Level
Slicing (GLS) method and Bit-Plane Slicing (BPS) method.
Keywords: Cerebrospinal Fluid (CSF) examination, Computed Tomography (CT), Image Enhancement methods, Leptomeningeal Metastases, Magnetic Resonance Imaging (MRI).
Received March 23, 2015; accepted August 12, 2015